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In the placebo group, a significant 70% increase in intestinal permeability was observed after the gluten challenge in contrast to the AT1001 treated patients in whom no changes in permeability were observed

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Metabolic studies showed that AOD9604-treated animals had increased lipolytic rates measured in isolated adipocytes, elevated circulating free fatty acid levels, and enhanced fatty acid oxidation rates

Mild soreness and swelling following treatment are normal and can be controlled with over-the-counter pain relievers like Tylenol

This creates theoretical concerns about cancer risk that require serious consideration